Kopka, Ihor E.: search on Z-Library

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1

The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

William K Hagmann, Philippe L Durette, Thomas Lanza, Nancy Jo Kevin, Stephen E de Laszlo, Ihor E Kopka, David Young, Plato A Magriotis, Bing Li, Linus S Lin, Ginger Yang, Theodore Kamenecka, Linda L C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 142 KB

english, 2001

2

CorrigendumCorrigendum to “The discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists”[Bioorg. Med. Chem. Lett. 12 (2002) 611]

Linus S Lin, Ihor E Kopka, Richard A Mumford, Plato A Magriotis, Thomas Lanza, Jr, Philippe L Durette, Theodore Kamenecka, David N Young, Stephen E de Laszlo, Ermenegilda McCauley, Gail Van Riper, Ush

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 61 KB

english, 2002

3

Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides containing extended alkyl residues At P1'

Craig K. Esser, Ihor E. Kopka, Philippe L. Durette, Richard K. Harrison, Lisa M. Niedzwiecki, Maria Izquierdo-Martin, Ross L. Stein, William K. Hagmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 238 KB

english, 1995

4

Dehydrohalogenation Reactions Using Hindered Lithium Dialkylamide Bases

Kopka, Ihor E., Nowak, Michael A., Rathke, Michael W.

Journal:

Synthetic Communications

Year:

1986

Language:

english

File:

PDF, 252 KB

english, 1986

5

The inhibition of C5a receptor binding by analogs of L-156,602, a cyclic hexadepsipeptide antibiotic

Philippe L. Durette, Ihor E. Kopka, Thomas J. Lanza, Joung L. Goulet, Joanne F. Kinneary, Charles G. Caldwell, Milton L. Hammond, Steven S. Bondy, Robert A. Zambias, Joshua Boger, Thomas Rollins, Salv

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 601 KB

english, 1992

6

Inhibition of matrix metalloproteinases by N-carboxyalkyl dipeptides: Enhanced potency and selectivity with substituted P1′ homophenylalanines

Soumya P. Sahoo, Charles G. Caldwell, Kevin T. Chapman, Philippe L. Durette, Craig K. Esser, Ihor E. Kopka, Scott A. Polo, Kelly M. Sperow, Lisa M. Niedzwiecki, Maria Izquierdo-Martin, Benedict C. Cha

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 259 KB

english, 1995

7

2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis

Hammond, Milton L., Kopka, Ihor E., Zambias, Robert A., Caldwell, Charles G., Boger, Joshua, Baker, Florence, Bach, Tom, Luell, Silvi, MacIntyre, D. Euan

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 2.03 MB

english, 1989

8

Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant

Ihor E. Kopka, Linus S. Lin, James P. Jewell, Thomas J. Lanza, Tung M. Fong, Chun-Pyn Shen, Zhege J. Lao, Sookhee Ha, Laurie G. Castonguay, Lex Van der Ploeg, Mark T. Goulet, William K. Hagmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1000 KB

english, 2010

9

The Discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists

Linus S. Lin, Ihor E. Kopka, Richard A. Mumford, Plato A. Magriotis, Thomas Lanza Jr., Philippe L. Durette, Theodore Kamenecka, David N. Young, Stephen E.de Laszlo, Ermenegilda McCauley, Gail Van Ripe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

10

Acylation of ketone silyl enol ethers with acetyl tetrafluoroborate. Synthesis of 1,3-diketones

Kopka, Ihor, Rathke, Michael W.

Journal:

Journal of Organic Chemistry

Year:

1981

Language:

english

File:

PDF, 349 KB

english, 1981

11

A novel one-pot synthesis of substituted 4-t-butyldimethylsilyloxy-thiazoles

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 257 KB

english, 1988

12

Role of HMPT and TMEDA in control of enolate stereochemistry for reactions of lithium amides with 3-pentanone

Fataftah, Zacharia A., Kopka, Ihor E., Rathke, Michael W.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 278 KB

english, 1980

13

Selective semisynthetic modification of L-156,602, a novel cyclic hexadepsipeptide antibiotic

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 284 KB

english, 1990

14

A convenient synthesis of 4-tert-butyl-5-benzofuranols and dihydrobenzofuranols

Zambias, Robert A., Caldwell, Charles G., Kopka, Ihor E., Hammond, Milton L.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 472 KB

english, 1988

15

Substituted N-(3,5-Dichlorobenzenesulfonyl)-l-prolyl-phenylalanine analogues as potent VLA-4 antagonists

Ihor E Kopka, David N Young, Linus S Lin, Richard A Mumford, Plato A Magriotis, Malcolm MacCoss, Sander G Mills, Gail Van Riper, Ermengilda McCauley, Linda E Egger, Usha Kidambi, John A Schmidt, Kathr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

16

N-(Arylacetyl)-biphenylalanines as Potent VLA-4 Antagonists

Bing Li, Stephen E de Laszlo, Theodore M Kamenecka, Ihor E Kopka, Philippe L Durette, Thomas Lanza, Jr, Malcolm MacCoss, Sharon Tong, Richard A Mumford, Ermengilda D McCauley, Gail Van Riper, John A S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 162 KB

english, 2002

17

Preparation of a series of highly hindered secondary amines, including bis(triethylcarbinyl)amine

Kopka, Ihor E., Fataftah, Zacharia A., Rathke, Michael W.

Journal:

Journal of Organic Chemistry

Year:

1980

Language:

english

File:

PDF, 1.00 MB

english, 1980

18

Characterization of zinc-binding sites in human stromelysin-1: stoichiometry of the catalytic domain and identification of a cysteine ligand in the proenzyme

Salowe, Scott P., Marcy, Alice I., Cuca, Gregory C., Smith, Catherine K., Kopka, Ihor E., Hagmann, William K., Hermes, Jeffrey D.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.31 MB

english, 1992

19

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Ihor E Kopka, Linus S Lin, Richard A Mumford, Thomas Lanza Jr., Plato A Magriotis, David Young, Stephen E DeLaszlo, Malcolm MacCoss, Sander G Mills, Gail Van Riper, Ermengilda McCauley, Kathryn Lyons,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

20

Preparation of hindered lithium amide bases and rates of their reaction with ether solvents

Kopka, Ihor E., Fataftah, Zacharia A., Rathke, Michael W.

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 436 KB

english, 1987

21

Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides

Chapman, Kevin T., Kopka, Ihor E., Durette, Philippe L., Esser, Craig K., Lanza, Thomas J., Izquierdo-Martin, Maria, Niedzwiecki, Lisa, Chang, Benedict, Harrison, Richard K.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.31 MB

english, 1993

22

Substituted 3-Amino Biaryl Propionic Acids as Potent VLA-4 Antagonists.

Ihor E. Kopka, et al. et al.

Journal:

Year:

2002

File:

PDF, 29 KB

2002

23

A total synthesis of (±)-dihydropalustrine

Harry D. Wasserman, Michael R. Leadbetter, Ihor E. Kopka

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 189 KB

english, 1984

24

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

William K Hagmann, Charles G Caldwell, Ping Chen, Philippe L Durette, Craig K Esser, Thomas J Lanza, Ihor E Kopka, Ravi Guthikonda, Shrenik K Shah, Malcolm MacCoss, Renee M Chabin, Daniel Fletcher, St

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 121 KB

english, 2000

25

Inhibition of Stromelysin-1 (MMP-3) by P 1 ‘-Biphenylylethyl Carboxyalkyl Dipeptides

Esser, Craig K., Bugianesi, Robert L., Caldwell, Charles G., Chapman, Kevin T., Durette, Philippe L., Girotra, Narindar N., Kopka, Ihor E., Lanza, Thomas J., Levorse, Dorothy A., MacCoss, Malcolm, Owe

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 633 KB

english, 1997

26

Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent

Hammond, Milton L., Zambias, Robert A., Chang, Michael N., Jensen, Norman P., McDonald, John, Thompson, Kathryn, Boulton, David A., Kopka, Ihor E., Hand, Karen M.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.58 MB

english, 1990

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